Indications

• Calcium d-glucarate can be used to enhance phase II detoxification by the liver.
• Calcium d-glucarate may help prevent various types of cancers including breast,
colon and liver cancers.
• Calcium d-glucarate helps reduce serum cholesterol levels.
• Calcium d-glucarate can help prevent platelet aggregation via its antioxidant
mechanism.
• Calcuim d-glucarate may be a useful therapy for women with fibrocystic breast
disease.

Ingredients

Each capsule of Calcium d Glucarate SAP contains
Calcium d glucarate ... 650 mg
Calcium d Glucarate SAP contains no preservatives, artificial flavour or colour, sugar,
dairy, starch, wheat, gluten, corn, soy or yeast.

Description

Calcium d-glucarate is a calcium salt of d-glucaric acid, which is a naturally-occurring substance. Glucaric acid is found in several fruits and vegetables, with its highest concentration being found in cruciferous vegetables, apples, oranges and grapefruits, and it is also made in small amounts in the human body.(1) d-Glucarate is an important substance that assists the body in its quest to detoxify and eliminate various toxins, hormones and carcinogens from the system. Two of the mechanisms that the body uses to detoxify are conjugation and glucuronidation, by which the body binds water-soluble substances to hormones or carcinogens, making it easier for them to be excreted. The enzyme β glucuronidase breaks the bonds formed during the detoxification process, which allows substances to recirculate in the body instead of being excreted. d-Glucarate inhibits β -glucuronidase, therefore encouraging the elimination of the potentially harmful toxins, carcinogens or hormones.

PURITY, CLEANLINESS AND STABILITY Third party testing is preformed on finished products to ensure Calcium d Glucarate SAP is free of heavy metals, pesticides, volatile organics, PCBs and other impurities. BIOCHEMISTRY In the body, calcium d.glucarate is converted through a series of reactions to the active molecule d.glucaro- 1,4.lactone, which inhibits beta-glucuronidase.(1, 2) d.Glucaro- 1,4.lactone has been found to be formed from d.Glucarate salt in the stomach. It is absorbed from the intestinal tract and transported via the blood stream to internal organs.(2, 3) It is mainly excreted via urine but also to a smaller extent in bile.(2) Calcium d.glucarate works to enhance detoxification by increasing glucuronidation, and therefore enhancing excretion of potentially toxic compounds. Glucuronidation occurs during the second phase of liver detoxification and is the process of taking hormones, carcinogens or other lipidsoluble toxins and conjugating them with glucuronic acid for them to be excreted via the biliary tract.(1) ƒÀ-Glucuronidase can deconjugate these toxins, making it possible for the toxins to be reabsorbed into the body.(1) d.Glucaro-1,4.lactone is able to inhibit the functioning of ƒÀ.glucuronidase, which results in an increase in excretion of the conjugated compounds and decreases the potential harm they could cause in the body.(1) Calcium d.glucarate has the ability to reduce the ƒÀ.glucuronidase activity of intestinal bacteria, which enhances enterohepatic circulation; this results in a reduction of cholesterol synthesis, and decreased serum cholesterol levels.(1)

CALCIUM D.GLUCARATE AND CANCER Elevated activity of ƒÀ.glucuronidase is associated with an increase in risk for several different cancer lines, but in particular hormone-dependent cancers like breast and prostate.(2, 3) Calcium d.glucarate is a precursor for d.glucaro-1,4.lactone, which increases the processing of carcinogens as well as other tumor promoters, by inhibiting ƒÀ.glucuronidase.(2, 4) d.Glucaro-1,4.lactone and its precursors alter steroidogenesis, which changes the hormonal environment and proliferative status of the target organs, which is one of the mechanisms that they work to exert their anticancer action.(2) d.Glucarate has the ability to suppress cell proliferation and inflammation, and can also induce apoptosis.(2, 4) In an animal model, researchers found that calcium d.glucarate was able to inhibit carcinogenesis during the initiation and promotion phases, by inhibiting protein tyrosine kinase.C activity and inducing transformation growth factor beta.(5) Supplementing the body with d.glucarates improves the natural defense system of the body for eliminating tumor promoters and carcinogens.(2)

CALCIUM d.GLUCARATE AND OXIDATIVE STRESS A study performed by J. Saluk-Juszczak (2010) examined the role of d.glucaro-1,4.lactone, sodium d.gluconate and calcium d.glucarate on blood platelets that were under oxidative stress.(6) It is known that platelet activation is essential in tumor progression, inflammation, allergic reactions and haemostasis.(6) The study measured in vitro levels of specific oxidative stress markers including: superoxide anion, carbonyl groups, 3.nitrotyrosine protein, thiobarbituric acid reactive substances and low molecular weight thiols.(6) Each of the substances tested significantly inhibited thrombin-induced arachidonic peroxidation as well as platelet protein oxidation/nitration induced by peroxynitrite.a strong oxidant formed intravascularly in vivo.(6) In the presence of the glucose derivative, there was a significant decrease seen in nitrotyrosine formation, thiol oxidation and carbonyl group generation.(6) These results indicate that gluconate salts may be helpful, via antioxidant mechanisms to prevent excessive platelet activation.(6)

CALCIUM d.GLUCARATE AND FIBROCYSTIC BREAST DISEASE Researchers examined fluid removed from cysts from women with fibrocystic breast disease (FBD) and compared the fluid to a control group of women who did not have benign breast disease. Results demonstrated that in selected cyst fluids, the level of ƒÀ.glucuronidase significantly influenced the ratio of unconjugated to glucuronidated estradiol.(7) Patients with fibrocystic breast disease fell into one of two distinct subpopulations, based on their level of ƒÀ.glucuronidase activity. One group had close to normal activity; however, the second group had an average serum ƒÀ.glucuronidase activity that was three times higher than the healthy controls.(7) This is an area that requires further research to determine what the cause of this variation is in the subgroups of women with FBD, but it does appear that elevated ƒÀ.glucuronidase activity may contribute to fibrocystic breast disease in some women.

Quantity

60 capsules/bottle

Dose

Take 1–4 capsules daily or as directed by your health care practitioner.

Potential side effects/Safety

Calcium d-glucarate may increase the excretion of some medication and hormones. If
you are taking any medications regularly, speak with your health care practitioner before
using this product.
No side effects have been reported with calcium
d glucarate. Many pharmaceuticals, especially hormones,
are metabolized in the liver by binding to glucuronic acid.
It is therefore possible that taking calcium d glucarate may
increase the elimination of certain pharmaceuticals and
hormones from the body.

References

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1. No authors listed. “Calcium d glucarate”. Altern Med Rev. 2002 Aug;7(4):336-9.
2. ZÓ taszek R., Hanausek M., Kilia ska Z.M., Walaszek Z. “The biological role of d glucaric
acid and its derivatives: potential use in medicine”. Postepy Hig Med Dosw (Online). 2008
Sep 5;62:451-62.
3. Walaszek Z., Szemraj J., Narog M., Adams AK., Kilgore J., Sherman U., Hanausek M.
“Metabolism, uptake, and excretion of a d glucaric acid salt and its potential use in cancer
prevention”. Cancer Detect Prev. 1997;21(2):178-90.
4. Heerdt, A.S., Young C.W., Borgen P.I. “Calcium glucarate as a chemopreventive agent in
breast cancer”. Isr J Med Sci 1995;31:101-105.
5. Webb T.E., Abou-Issa H., Stromberg P.C., et al. “Mechanism of growth inhibition of
mammary carcinomas by glucarate and the glucarate:retinoid combination”. Anticancer Res
1993;13:2095-2100.
6. Saluk-Juszczak J. “A comparative study of antioxidative activity of calcium d glucarate,
sodium d gluconate and d glucono 1,4 lactone in a human blood platelet model”. Platelets.
2010;21(8):632-40. Epub 2010 Sep 27.
7. Minton J.P., Walaszek Z., Schooley W., Hanausek-Walaszek M., Webb T.E.
“ β Glucuronidase levels in patients with fibrocystic breast disease”. Breast Cancer Res
Treat. 1986;8(3):217 22.