Indications

To promote optimal terrain for maintenance and restoration of healthy gastrointestinal and immune function; Hypercholesterolemia

Ingredients

Each scoop contains:
Arabinogalactan (Larix occidentalis) 4.7 g

Description

• Lower rates of bloating and flatulence due to lower rate of fermentation, and no adaptation period required;
• Similar cholesterol modulating abilities and prebiotic activity promoting a wider, more specifically proven range of probiotic growth, all at lower doses;
• Stimulates immune function and increases cytotoxic phagocytosis;
• Wider pH and temperature stability;
• Increased safety, with increased water solubility and lower viscosity;
• Neutral taste, low caloric value (1.4 kcal/g) and no glycemic response.

Larch Arabinogalactan
Larch arabinogalactan consists of galactose and arabinose side-chains in a 6:1 ratio. It is a long, denselybranched polysaccharide containing no starch, with a galactan backbone. Larch arabinogalactan is a safe and effective bulking laxative which promotes gut motility, normalizes and improves bowel function by decreasing the incidence of constipation, increasing fecal weight and decreasing transit time. A multifunctional dietary fibre, larch arabinogalactan has been approved by the USFDA and other authorities for its diverse benefits on human health, with potential therapeutic use as an immune stimulating agent and cancer protocol adjunct(1, 2). Prebiotic Activity and Gastrointestinal Health Selective Stimulation of Growth of Beneficial Microflora Evidence from human and in vitro studies demonstrate the ability of larch arabinogalactan to exhibit specific and positive effects on gastrointestinal health. It has been specifically shown to increase anaerobes such as Bifidobacteria and Lactobacillus species, while decreasing Clostridia and E. coli(3, 4, 5, 6). Increased Production of Short-Chain Fatty Acids Reduction of Ammonia Larch arabinogalactan has demonstrated the ability to lower colonic pH, stimulating an environment favouring the development of beneficial bacteria, by increasing short-chain fatty acids including acetate, propionate and most importantly, butyrate. Acetate and propionate are used as energy sources in the brain, muscle and heart; butyrate is a major fuel source for gastrointestinal mucosal cells(7, 8, 9, 10, 12). Larch arabinogalactan decreases the generation and absorption of ammonia in the gut(6, 11, 12), preventing its accumulation and consequent damage to gastrointestinal epithelium. Effects on Cardiovascular Health, Cholesterol, Diabetes, Glucose and Insulin Control Viscous, soluble fibres are well established as an effective method of reducing LDL cholesterol by up to 30% in combination with dietary modification, and producing clinically significant reductions in cardiovascular disease risk. Soluble fibre intake has been associated with reduced glucose and insulin responses. These effects have been attributed to the formation of a gel-like consistency in the stomach, thereby delaying gastric emptying and absorption. Soluble fibres increase intestinal transit time resulting in decreased absorption of carbohydrates in the upper jejunum and relieving insulin demand(13). High Digestive Tolerance and Advantages Over Other Fibre Sources The highly branched structure of larch arabinogalactan provides for it to be freely soluble, dissolving completely in hot or cold water and liquids, and gives it a lower viscosity than other fibres when dissolved, allowing for increased patient compliance and ease of use(14). It is highly stable within a wide temperature and pH range, and provides all the benefits of other fibres with minimal to no side effects such as bloating and flatulence(6), due to its branched structure and therefore slow rate of fermentation. A lowcalorie (1.4 kcal/g) substance, larch arabinogalactan has been reported to have no glycemic response(6) and has a neutral taste. Immune-Stimulating Arabinogalactans are capable of enhancing the immune response to bacterial infection by stimulating phagocytosis, competitive binding of bacterial fimbriae and bacterial opsonization particularly in Gram-negative bacterial such as E. coli and Klebsiella(2, 15). A study by D'Adamo in a pediatric population shows a reduction in occurrence and severity of otitis media with supplemental larch arabinogalactan(15). These immune-stimulating properties have been suggested to have potential benefits in the treatment of chronic diseases, including HIV/AIDS, chronic fatigue syndrome, viral hepatitis, and autoimmune disorders such as multiple sclerosis. Macrophages and lymphocytes treated with larch arabinogalactan exhibited a stimulatory effect of immune function in a 2005 study by Choi et al.(18). Larch arabinogalactan has been shown to increase CD4 counts while reducing susceptibility to opportunistic pathogens(2, 15). Due to its ability to stimulate NK cell and macrophage cytotoxicity, the immune system in general, and block the metastasis of tumour cells to the liver via inhibition of lectin receptor sites, larch arabinogalactan has been implicated as a potential adjunct to cancer therapies

Dose

Adults: 1 scoop, 1 to 3 times daily, stirred in 8 oz. of water or juice, or as directed by your
health care practitioner.
Children: 1/3 to 1 scoop, 1 to 3 times daily, stirred in 8 oz. of water or juice, or as directed
by your health care practitioner.
Stir Arabino SAP into 8 oz. of water or juice, and always follow prebiotic fibres with
additional water intake (an additional 8 oz.) and ensure optimal daily hydration
(minimum of 64 oz./day).

Potential side effects/Safety

Larch arabinogalactan has USFDA GRAS status and is considered extremely safe, with
minimal to no toxicity. Caution should be exercised if you have difficulty swallowing

References

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1. Advanced Dietary Fibre. 2000;38:443-451.
2. Altern Med Rev. 2000;5(5):463-6.
3. Brit J Ntr.1990;63:17.
4. Int J Food Microbio. 1994;24:199.
5. Anaerobe. 1995;1:275.
6. J Am Coll Nutr. 2001;20(4):279-285.
7. Am J Clin Nutr. 2001;73:415S-420S.
8. Am J Clin Nutr. 2001;73:406S.
9. J Nutr. 2000;130:391S.
10. Curr Pharma Design. 2005;11:75.
11. Altern Med Rev. 1999;4(2):96.
12. Br J Nutr. 1990;63(1):17-26.
13. Modern Nutrition in Health and Disease, 9th Ed.. 1999:679-698.
14. J Pharm Sci. 1961;50(7):560.
15. J Naturopathic Med. 1996;6:33-37.
16. Invasion Metastasis. 1991;11:348-355.
17. Cancer Immunol Immunother. 1993;36:237-44.
18. J Med Food. 2005;8(4):446-453.