Genestra Brands - Phos Choline

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Indications
Ingredients
Description
Quantity
Dose
Safety

Phos Choline

Manufacturer:	Genestra Brands
Code:	10526
NPN:	80006244

Indications
Ingredients
Description
Quantity
Dose
Safety

Indications

To help maintain and support liver health.

Ingredients

Calories, Calories from Fat, Soy Lecithin

Description

Lecithin-derived phospholipid formula
• Provides 2880 mg of phosphatides per daily dose
• Supports liver health

Phos Choline provides phospholipids that help to support liver function. Phosphatidyl-choline (PC) is the primary phospholipid (also known as phosphatide) found in lecithin.1

It is an important component of cell membranes and is highly concentrated in hepatocytes. 2,3 All lipoproteins are rich in PC, and are primarily produced in the liver.3

Normal PC levels may help to prevent hepatic lipid accumulation as PC is necessary for the production and secretion of very low density lipoproteins (VLDL), which transport triglycerides from the liver. 2,3 PC deficiencies may lead to VLDL and triglyceride buildup in the liver, which negatively affects liver function and health.3

Recent in vitro studies show that hepatocytes also overproduce free radicals when grown in choline deficient medium; excess reactive oxygen species production can lead to DNA damage and impair liver function.4 In a randomized, double blind trial, 57 healthy adults were fed diets low in choline. After six weeks of depletion, fatty liver, liver damage and/or muscle damage was observed among 68% of participants.5 When choline was replenished in the diet, the organ dysfunction was resolved in all participants within six weeks.5

REFERENCES

1. Patterson KY, Bhagwat SA, Williams JR, Howe JC, Holden JM. January 2008 (http://www.ars.usda.gov/SP2UserFiles/Place/80400525/Data/Choline/Choln02.pdf).

2. Duric, M, Sivanesan, S, Bakovic, M. Eur. J. Lipid Sci. Technol. 2012; 114: 389-398.

3. Cole, LK, Vance, JE, Vance, DE. Biochimica et Biophysica Acta. 2012; 1821: 754-761.

4. Zeisel, SH. Mutation Research. 2012; 733: 34- 38.

5. Fischer, LM, daCosta, KA, Kwock, L, Stewart, PW, Lu, TS, Stabler, SP, Allen, RH, Zeisel, SH. Am J Clin Nutr. 2007; 85: 1275-85.

Quantity

90 caps

Dose

Recommended Adult Dose: Take 2 softgels 2 times daily with meals or as recommended by your healthcare practitioner.

Potential side effects/Safety

Risk Information: Consult your healthcare practitioner prior to use if you are pregnant or breastfeeding.

Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. www.nhpassist.com © 2014 NDAssist Inc. and/or its affiliates. All rights reserved.

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Manufacturer:

Genestra Brands

Code:

10526

NPN:

80006244

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