Indications

Gentian is traditionally used in Herbal Medicine as a digestive tonic and
bitter to help stimulate appetite, aid digestion and help relieve digestive
disturbances.

Ingredients

Black Walnut Hull, Clove Bud, Gentian Root, Pumpkin Seed Extract, Quassia Bark, Sweet Wormwood Herb, Yarrow Flower

Description

Combination of black walnut and natural plant ingredients that relieve digestive upsets
Traditionally used in Herbal Medicine as a digestive tonic to aid digestion and help relieve dyspepsia
Quassia, black walnut, and pumpkin seeds are traditionally used in Herbal Medicine as a vermifuge
Provides 400 mg of black walnut hull, quassia bark, and yarrow flower per daily dose
Includes 200 mg each of gentian root and pumpkin seed extract, 300 mg of sweet wormwood herb and 100 mg of clove bud per daily dose

Black Walnut Capsules is a blend of herbs that are traditionally used in Herbal Medicine to help alleviate digestive disturbances. Black walnut, quassia, wormwood and gentian root all contain extremely bitter compounds, including tannins, quassin, absinthin, and amarogentin.1-4 These bitters cause nerves on the taste buds to increase the release of saliva and gastric juices that aid in digestion.4 Bitters can also bind receptors on endocrine cells of the gastrointestinal tract and pancreas, which results in the secretion of the peptide hormone cholecystokinin.5 In turn, this releases bile salts and pancreatic digestive enzymes, increasing gastric motility.5 Gentian root and quassia may help relieve dyspepsia by increasing prostaglandin-mediated cytoprotection in the gastric membrane; prostaglandins stimulate the release of mucous and sodium bicarbonate in the stomach.2,6,7 Quassia, black walnut and pumpkin seeds are also traditionally used in Herbal Medicine as a vermifuge (helps in the expulsion of parasitic worms).

NPN 80043531
07546180

1. Milind, P, Deepa, K. Walnut: not a hard nut to crack. International Research Journal of Pharmacy. 2011; 2(5): 8-17.
2. Ocampo, R, Mora, G. (2011). Chapter 11 Ethnomedicine of Quassia and Related Plants in Tropical America. In M. Rai, D. Acharya, JL. Rios (Eds.), Ethnomedicinal Plants Revitalization of Traditional Knowledge of Herbs (pp. 301-332). Boca Raton, FL: Taylor & Francis Group, LLC.
3. Levit, A, Nowak, S, Meyerhof, W, Behrens, M, Peters, M, Niv, MY. The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. FASEB Journal. 2014; 28(3): 1181-1197.
4. Godstime, O, Felix, E, Augustina, J, Christopher, E. Mechanisms of Antimicrobial Actions of Phytochemicals against Enteric Pathogens - A Review. Journal of Pharmaceutical, Chemical and Biological Sciences. 2014; 2(2):77-85.
5. Valussi, M. Functional foods with digestion-enhancing properties. International Journal of Food Sciences and Nutrition. 2012; 63(S1): 82-89.
6. Niiho, Y, Yamazaki, T, Nakajima, Y, Yamamoto, T, Ando, H, Hirai, Y, Toriizuka, K, Ida, Y. Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats. J Nat Med. 2006; 60: 82-88.
7. Wallace, JL. Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn-t the Stomach Digest Itself? Physiol Rev. 2008; 88: 1547-1565.

Quantity

180 caps

Dose

Recommended Adult Dose: Take 2 capsules 2 times daily, 15 to 60 minutes before meals, or as recommended
by your healthcare practitioner. Consult your healthcare practitioner for use beyond 14 days. For occasional
use only.

Potential side effects/Safety

Risk Information: Do not use if you are pregnant, breastfeeding, have acute stomach irritation,
inflammation, stomach or duodenal ulcers or an allergy to plants of the Asteraceae family. Consult your
healthcare practitioner prior to use if you are taking anticoagulant, cardiac, hypotensive or hypertensive
medications. Consult your healthcare practitioner if symptoms persist or worsen. Stop use if allergy
occurs. Some people may experience headaches.
Consult your healthcare practitioner prior to use if you are taking anticoagulant,
cardiac, hypotensive or hypertensive medications. Consult your healthcare
practitioner if symptoms persist or worsen. Hypersensitivity, has been known to
occur; in which case, discontinue use. Some people may experience headaches.